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In spite of large binding to plasma proteins (ninety eight-99%) - largely albumin also to a lesser extent ?1-acid glycoprotein - diazepam is widely distributed into tissues and crosses the blood-Mind barrier and is extremely lipid soluble, which leads to the Preliminary consequences to minimize quickly as it truly is redistributed into Fats deposit
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Despite high binding to plasma proteins (98-ninety nine%) - primarily albumin also to a lesser extent ?1-acid glycoprotein - diazepam is greatly distributed into tissues and crosses the blood-brain barrier and is extremely lipid soluble, which causes the Original outcomes to lower quickly as it's redistributed into Unwanted fat deposits and tissues
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